1761	Louis XV authorises the creation of a Veterinary and Rural Economy School in Lyon.
1762	Honoré Fragonard,appointed first director of Lyon Royal School.
1764	Bourgelat decides to transfer the school from Lyon to Paris. Jean-André Thoin,gardener of the King's cabinet , dies.His son,André, succeeds him as Head gardener of the Royal cabinet of Natural History.(The future Natural History Muséum)
	In Lyon, Honoré Fragonard works on the possible toxicity of several plant remedies. As well as his very high professional qualities and knowledge of natural sciences, he was also very good at organising studies and giving lectures.
1766	In October, the Royal Veterinary School of Alfort opened as did the “Jardin des Plantes” and Fragonard is in charge. He also gives lectures in botany and pharmacy. The students (90) grow medicinal plants, collecting, drying, preparing extracts, and then distilling then, in order to produce drugs. As at Lyon, the garden was very important for the veterinary science, producing treatments for use in animals.
1767	Plants useful to mankind are also grown giving an ethno-botanical connotation to the collection. A Head-Gardener, Mr. Bredin, is appointed to help Fragonard
1768	Mr. Chalmat, gardener is replaced by Mr. Boulogne. François Fragonard assists his brother in the management of the pharmacy.
1770	Due to personal problems between Honoré Fragonard and Bourgelat, Fragonard leaves the school. Fragonard’s anatomical works are published by Bourgelat without his permission
1771	A new garden is developed showing food, useful and toxic plants. Mr. Courbebaisse replaces Fragonard, and classifies plants using the Joseph Pitton de Tournefort system. The garden’s first greenhouse is built.
1779	Mr. Millet replaces Bredin as Head-Gardener. Pierre Marie August Broussonnet is appointed doctor at the prestigious Medical Faculty of Montpellier. He becomes a knowledgeable botanical member of the Agricultural Academy and Science Academy and is named Perpetual Secretary.
1782	Buffon sends Dauberton , who was Professor of Rural Economy at the Royal College,as well as Broussonnet to Alfort to create a Rural Economy Section.They give lectures on botany to students at the school. They are helped by Professor Gilbert .
1787	Broussonnet establishes the Paris Linnaean Society with six colleagues (Daubenton, Redouté,Desfontaines, Fourcroy, Lavoisier and Thouin). Meanwhile, Broussonnet is appointed director of Montpellier Botanical Garden (the oldest botanical garden in France created in 1593) and unanimously elected to the Science Académy in Paris. He acclimatised the first Ginkgo biloba in Montpellier and also the first Broussonnetia papyrifera and Cercis siliquastrum. The Royal Treasury is empty: the school funding is dramatically reduced.
1789	The Royal Veterinary School becomes the National Veterinary School but the school is threatened with closure or transfer..
1790>1800	Life for the school is very difficult during the French Revolution.
1801	The law of year III introduces the teaching of “silk farming” and “bee keeping” (with 18 hives) at Alfort.
1803	The Alfort Imperial Veterinary School botanical activities are the following: 1. Systematic study of plants according to the Tournefort system, then Linnaeus, then Jussieu. 2. Study of toxic plants (with plant identification in the countryside). 3. Study of spices and medicinal plants. 4. Cultivation of fodder plants, bee attracting and silk related plants. 5. Cultivation of useful plants to man, dyeing and textile plants.
1818	The school becomes Royal
1848	The school becomes National
1852	The school becomes Imperial
1871	The school becomes definitively National
1882	The "Herb garden" is re-organised. The collection now contains 1600 species classified with the “Baillon system”.
1910	Great floods of the rivers Seine and Marne. The school is completely flooded. Consequently, earth moving and drainage systems are installed using clinker. The original soil is greatly modified which decreases its quality. For this reason, even nowdays when planting it is necessary add good soil.
1914 1918	Military occupation of the school. Part of the Botanic Garden is transformed into a vegetable garden.
1930	The Botanic Garden looses 4000m2, due to the building of a new science laboratory.
1939 1945	The school is prepared for National Defence. Part of the Botanic Garden is believed to be transformed into a vegetable garden.